Comparative serum bactericidal activities of ceftizoxime and cefotaxime against intermediately penicillin-resistant Streptococcus pneumoniae

Bactericidal activities of ceftizoxime and cefotaxime against Streptococcus pneumoniae.

Patel et al. (4) compared the serum bactericidal titers (SBTs) and the time serum drug concentrations remained above the MICs (T . MIC) of ceftizoxime and cefotaxime against three intermediately penicillin-resistant Streptococcus pneumoniae isolates. MICs were # 1.0 mg/ml, SBTs were . 1:2, and T . MIC exceeded 50% of dosage intervals. They concluded that ceftizoxime’s longer T . MIC compensates...

In vitro Activities of Penicillin G, Cefotaxime, Fosfomycin, Fusidic Acid and Vancomycin Against Streptococcus pneumoniae

Penicillin-resistant Streptococcus Pneumoniae

Streptococcus pneumoniae is a major cause of pneumonia, meningitis, septicemia, acute otitis media, and other serious infections, severely affecting infants, young children, and the elderly. In the past, S. pneumoniae was uniformly susceptible to penicillin, which remained the drug of choice for serious infections. However, since the mid-1960s, resistance to penicillin, which was first reported...

Comparative in-vitro activities of amoxycillin and penicillin against Streptococcus pneumoniae isolates.

Sir, In a recent issue of this Journal, Verhaegen & Verbist reported on the in-vitro activities of 21 -lactams against penicillin-susceptible and -resistant isolates of Strepto coccus pneumoniae. The results of this investigation are surprising because they suggest that amoxycillin is less active than penicillin against these strains. We have recently determined the in-vitro susceptibilities of...

Bactericidal activities of cefprozil, penicillin, cefaclor, cefixime, and loracarbef against penicillin-susceptible and -resistant Streptococcus pneumoniae in an in vitro pharmacodynamic infection model.

We examined the bactericidal activities of penicillin, cefprozil, cefixime, cefaclor, and loracarbef against three clinical isolates of Streptococcus pneumoniae which were susceptible, moderately susceptible, and resistant to penicillin. An in vitro two-compartment glass infection model was used to simulate human pharmacokinetics in the presence of bacteria. Also, changes in organism susceptibi...